Clinical Trials

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Current as of 11/2023. For a complete list of clinical trials currently available at our site, call Kari at 732-840-8880 x-117

Multiple Cancers

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Tissue 32 HH-PPT-0001
Open

Collection of blood and tissue samples from cancer and non-cancer subjects for validation of a novel blood-based multi-cancer screening test

Non-Small Cell Lung Cancer (NSCLC)

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Revolution Medicine RMC-4630-03
Closed

A Phase 2, open-label, multicenter study of the combination of RMC-4630 and Sotorasib for non-small cell lung cancer (NSCLC) subjects with KRAS G12C mutation after failure of prior standard therapies

SARS-CoV-2 Prevention

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EIMPRIS ESR 22-21698
Closed

Real world evaluation of the effectiveness of AZD7442 for prevention of SARS-CoV-2 infection in immuno-suppressed cancer patients.

Acute Myeloid Leukemia

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Bio Path BP1001-201-AML
Closed

Phase IIa single-arm, open-label, two-stage clinical trial to evaluate the safety, pharmacokinetics, pharmacodynamics, and efficacy of BP1001 (a liposomal Grb2 antisense oligonucleotide) in combination with low-dose Cytarabine (LDAC) in patients with previously untreated acute myeloid leukemia (AML) who are ineligible for intensive induction therapy.

Multiple Cancers

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MT Group MTG-022
Open

Translational Medicine: Discovery and evaluation of biomarker/pharmocogenomics for the diagnosis and personalization management of patients.

Multiple Cancers

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Seer-020102
Closed

A prospective blood sample collection study to evaluate a panel of protein-based biomarkers.

Multiple Cancers

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Freenome FRNM-003
Closed

A prospective multi-center observational study to validate a blood-based test for the early detection of colorectal cancer by collecting blood samples from average-risk participants who will undergo a routine screening colonoscopy.

Multiple Cancers

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Klus Pharma, Inc.
Closed

Phase I-II, First-in-Human Study of A166 in Patients with Locally Advanced/Metastatic Solid Tumors which are Human Epidermal Growth Factor Receptor 2 (HER2)-Positive who did not Respond or Stopped Responding to Approved Therapies and Patients with HER2 Positive (by ISH or NGS) or Low Expressing (by IHC) Solid Tumors who did not Respond or Stopped Responding to Approved Therapies.

Lung Cancer (NSCLC and SCLC)

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Arcus – ABI54C SP0002
Open

A Phase 2 Study to Evaluate the Safety and Efficacy of AB122 Alone, AB154 in Combination with AB122 and AB154 in Combination with AB122 and AB928 in Front-Line Non-Small Cell Lung Cancer.

Lung Cancer (NSCLC and SCLC)

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ARRAY BioPharma – ARRAY 808-202
Open

A Phase 2, Open-Label Study of Encorafenib + Binimetinib in Patients with BRAF V600E-mutant non-small Cell Lung Cancer.

Lung Cancer (NSCLC and SCLC)

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Blue Note PROT001
Closed

A double blinded, randomized, controlled, adaptive trial to compare effectiveness of two digital software medical devices (attune and cerena) as interventions for physical and emotional health in adjunctive oncology treatment, in order to determine relative impact on anxiety and depressive symptoms in stage I-III breast cancer and I-III non-small cell lung cancer.

Lung Cancer (NSCLC and SCLC)

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Helsinn ANAM-17-21
Closed

A phase 3, randomized, double-blind, placebo-controlled, multicenter study to evaluate the efficacy and safety of Anamorelin HCI for the treatment of malignancy associated weight loss and anorexia in adult patients with advanced non-small cell lung cancer (NSCLC)

Lung Cancer (NSCLC and SCLC)

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Lunar EF-24
Closed

A pivotal, randomized, open-label study of tumor treating fields (TTFields) concurrent with standard of care therapies for treatment of stage 4 non-small cell lung cancer (NSCLC) following platinum failure

Lung Cancer (NSCLC and SCLC)

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MS201923_0050
Closed

A Phase II open label, single arm study of Berzosertib (M6620) in combination with Topotecan in participants with relapsed platinum-resistant small cell lung cancer

Lung Cancer (NSCLC and SCLC)

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ARC7 AB154CSP0002
Open

A phase 2 Open-Label study to evaluate the safety and efficacy of AB122 and AB928 in 1st line NSCLC

Lung Cancer (NSCLC and SCLC)

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Genentech MO43576
Closed

A randomized, multi-centered, open label, cross-over study to evaluate participant and healthcare professionals reported preference for subcutaneous atezolizumab compared with atezolizumab formulation in participants with non-small cell lung cancer (NSCLC)

Febrile Neutropenia (Breast Cancer, Lung Cancer, Prostate Cancer, NHL)

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Amgen 20170758
Closed

A prospective observational study to estimate the incidence of febrile neutropenia (FN) among subjects with non-myeloid malignancies at high risk for FN and receiving Neulasta® (pegfilgrasim) Onpro® kit or other physician choice options for prophylaxis of FN

Non-Hodgkin’s Lymphoma, Chronic Lymphocytic Leukemia, Hodgkin’s Lymphoma, Small Lymphocytic Leukemia

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Incyte – INCMOR0208-101
Open

A Phase 1b/2a Basket Study to Evaluate the Safety, Tolerability, Pharmakokinetics and Efficacy of Combination Therapy with the anti CD19 Monoclonal Antibody Tafasitimab and the PI3K§ Inhibitor Paraclisib in Adult Participants with Relapsed/Refractory Non-Hodgkin’s Lymphoma or Chronic Lymphocytic Leukemia.

Non-Hodgkin’s Lymphoma, Chronic Lymphocytic Leukemia, Hodgkin’s Lymphoma, Small Lymphocytic Leukemia

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LOXO-BTK-20020
Closed

A phase 3, open-label, randomized study of LOXO-305 versus Investigator’s choice of Idealisib plus Rituximan or Bendamustine plus Rituximab in BTK inhibitor pretreated CLL and SLL

Non-Hodgkin’s Lymphoma, Chronic Lymphocytic Leukemia, Hodgkin’s Lymphoma, Small Lymphocytic Leukemia

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LOXO-BTK 20023
Closed

A phase 3 open-label, randomized study of Pirtobrutinib (Loxo-305) verses Bendamustine plus Rituximab in BTK Inhibitor untreated Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (BRUIN CLL-313)

Non-Hodgkin’s Lymphoma, Chronic Lymphocytic Leukemia, Hodgkin’s Lymphoma, Small Lymphocytic Leukemia

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GenFleet GFH009X2101
Open

A phase 1 open label, dose escalation and dose expansion study of intravenous GFH009 single agent in patients with relapsed/refractory hematologic malignancies.

Non-Hodgkin’s Lymphoma, Chronic Lymphocytic Leukemia, Hodgkin’s Lymphoma, Small Lymphocytic Leukemia

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Astra Zeneca/Acerta ACE-CL-311
Closed

A randomized, multicenter, open-label, phase 3 study to compare the efficacy and safety of Acalabrutinib (ACP-196) in combination with Venetoclax with and without Obinutuzumab compared to investigator’s choice of chemoimmunotherapy in subjects with previously untreated chronic lymphocyctic leukemia without del(17p) or TP53 mutation

Non-Hodgkin’s Lymphoma, Chronic Lymphocytic Leukemia, Hodgkin’s Lymphoma, Small Lymphocytic Leukemia

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Seattle Genetics SGN35-027
Open

Phase IV Multiple Part Trial of Brentuximab Vedotin in Classical Hodgkin Lymphoma Subjects To assess the CR rate at end-of-treatment (EOT) with brentuximab vedotin, nivolumab, doxorubicin, and dacarbazine (AN+AD) in subjects with previously untreated advanced cHL

Non-Hodgkin’s Lymphoma, Chronic Lymphocytic Leukemia, Hodgkin’s Lymphoma, Small Lymphocytic Leukemia

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InnoCare Pharma Inc. ICP-CL-00107
Open

Phase II, open-label, dose-escalation study to evaluate the safety, tolerability and pharmacokinetics of a novel BTK inhibitor, ICP-022. During this study, dose escalation will be conducted in patients diagnosed with refractory/relapsed (r/r) B-cell malignancies including only patients with Grades 1-3a follicular lymphoma (FL); marginal zone lymphoma (MZL); mantle cell lymphoma (MCL); and chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL)

Non-Hodgkin’s Lymphoma, Chronic Lymphocytic Leukemia, Hodgkin’s Lymphoma, Small Lymphocytic Leukemia

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Hutchison Medi Pharma 2018-523-00US1A
Open

Phase I, Open-Label Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Preliminary Efficacy of HMPL-523 in Patients with Relapsed or Refractory Lymphoma

Non-Hodgkin’s Lymphoma, Chronic Lymphocytic Leukemia, Hodgkin’s Lymphoma, Small Lymphocytic Leukemia

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MEI Pharma, Inc. ME-401-003
Open

Phase 2, Open Label, Study of ME-401 in rrFollicular Lymphoma After Failure of Two or More Prior Systemic Therapies. This is a global, multicenter, open-label, single-arm, Phase 2 study of the PI3Kδ inhibitor ME-401 in subjects with relapsed/refractory FL. ME-401 will be administered orally at a dose of 60 mg given once a day. A cycle of treatment is 28 days in duration. Treatment with ME-401 can be administered based on a continuous schedule (CS) or an intermittent schedule (IS)

Non-Hodgkin’s Lymphoma, Chronic Lymphocytic Leukemia, Hodgkin’s Lymphoma, Small Lymphocytic Leukemia

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Acerta ACE-LY-003
Closed

Open-label, Phase 1b/2 Study of Acalabrutinib Alone or in Combination Therapy in Subjects with B-cell Non-Hodgkin Lymphoma. Acalabrutinib: is a potent covalent inhibitor of Btk, specifically designed to be a more potent and selective inhibitor of Btk to avoid off-target side effects as seen with ibrutinib

Non-Hodgkin’s Lymphoma, Chronic Lymphocytic Leukemia, Hodgkin’s Lymphoma, Small Lymphocytic Leukemia

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Incyte INCB 50465-203 CITADEL-203
Open

A Phase 2, Multicenter, Open-Label Study of INCB050465, a PI3Kδ Inhibitor, in Relapsed or Refractory Follicular Lymphoma (CITADEL-203)

Non-Hodgkin’s Lymphoma, Chronic Lymphocytic Leukemia, Hodgkin’s Lymphoma, Small Lymphocytic Leukemia

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Acerta ACE-LY-308
Open

Phase 3, Double-blind, Placebo-controlled, Study of BR alone vs in Combination with Acalabrutinib (ACP-196) in Subjects with Previously Untreated Mantle Cell Lymphoma (MCL)

Non-Hodgkin’s Lymphoma, Chronic Lymphocytic Leukemia, Hodgkin’s Lymphoma, Small Lymphocytic Leukemia

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BeiGene BGB-3111-306
Open

Phase 3, Randomized, Open-Label, Study Comparing Zanubrutinib (BGB-3111) plus Rituximab vs Bendamustine plus Rituximab in 1st Line Mantle Cell Lymphoma Who Are Ineligible for Stem Cell Transplantation due to age or Comorbidities

Non-Hodgkin’s Lymphoma, Chronic Lymphocytic Leukemia, Hodgkin’s Lymphoma, Small Lymphocytic Leukemia

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Nanjing Zenshine ZX-101A-101
Closed

A phase 1/2a, dose-escalation and dose-expansion study of ZX-101A in patients with relapsed/resistant or refractory advanced hematologic malignancies (NHL, iNHL, CLL, SLL)

Non-Hodgkin’s Lymphoma, Chronic Lymphocytic Leukemia, Hodgkin’s Lymphoma, Small Lymphocytic Leukemia

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Adagene ADG106-1001
Closed

A phase 1 open-label, dose-escalation, study of CD137 agonist ADG106 administered intravenously in patients with advanced or metastatic solid tumors and/or Non-Hodgkin Lymphoma/ Hodgkin Lymphoma

Non-Hodgkin’s Lymphoma, Chronic Lymphocytic Leukemia, Hodgkin’s Lymphoma, Small Lymphocytic Leukemia

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Hutchison Medi Pharma 2018-689-00US1
Open

Phase 1, Open-Label Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Preliminary Efficacy of HMPL-689 in Relapsed or Refractory Lymphoma [CLL, SLL, FL, MZL, LPL/WM, and MCL]

Previously Treated Renal Cell Carcinoma (RCC), Urothelial Carcinoma (UC), Gastric or Gastro-esophageal Junctional (GEJ) Adenocarcinoma, Colorectal Adenocarcinoma (CRC)

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Pharmacyclics PYCY-1128-CA
Closed

A phase 1b/2 study of Ibrutinib combination therapy in selected advanced gastrointestinal and genitourinary tumors

Myelofibrosis (MF) and Essential Thrombocythermia (ET)

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Incyte INCB-MA-MF-401
Closed

Prospective, longitudinal, non-interventional study of disease burden and treatment of patients with low-risk myelofibrosis (MF) or high risk essential thrombocythemia (ET) or ET patients receiving ET-directed therapy

Myelofibrosis (MF) and Essential Thrombocythermia (ET)

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Incyte INCB 39110-213
Closed

A 2-part, phase 2, open-label study of the safety, tolerability, and efficacy of Itacitinib immediate release in participants with primary myelofibrosis or secondary myelofibrosis (post–polycythemia vera myelofibrosis or post–essential thrombocythemia myelofibrosis) who have received prior Ruxolitinib and/or Fedratinib monotherapy

Myelofibrosis (MF) and Essential Thrombocythermia (ET)

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Incyte INCB 50465-304
Closed

A randomized, double-blind, placebo-controlled study of the PI3Kδ inhibitor Parsaclisib plus Ruxolitinib in participants with Myelofibrosis who have suboptimal response to Ruxolitinib.

Myelofibrosis (MF) and Essential Thrombocythermia (ET)

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Incyte INCB 50465-313
Closed

A phase 3, randomized, double-blind, placebo-controlled study of the combination of PI3Kδ inhibitor Parsaclisib and Ruxolitinib in participants with Myelofibrosis

Chronic Myelomonocytic Leukemia or MDS or AML

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Prelude PRT1419-03
Closed

A phase 1, open-label, multicenter, dose escalation study of PRT1419 injection in patients with relapsed/refractory hematologic malignancies (AML, CMML, high risk MDS, or MDS/MPN overlap syndrome)

Chronic Myelomonocytic Leukemia or MDS or AML

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Takeda/Millenium P-3001-MLN-4924
Closed

A phase 3, randomized, controlled, open-label, clinical study of Pevonedistat plus Azacitidine versus single-agent Azacitidine as first-line treatment for patients with higher-risk myelodysplastic syndromes, chronic myelomonocytic leukemia, or low-blast acute myelogenous leukemia. Prevonedistat plus zacitidine versus single-agent Azacitidine as first-line treatment for patients with higher-risk myelodysplastic syndromes, chronic myelomonocytic leukemia, or low-blast acute myelogenous leukemia

Newly Diagnosed Higher Risk Myelodysplastic Syndrome (MDS)

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Innovent CIBI188A103
Closed

A phase 1b study evaluating the safety and efficacy of IBI188 in combination with Azacitidine in subjects with newly diagnosed higher risk Myelodysplastic Syndrome (MDS)

Breast Cancer

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Astra-Zeneca D9670C00001 – Destiny 06
Open

A Phase 3, Randomized, Multi-center, Open Label Study of Trastuzumab Deruxtecan (T DXd) Versus Investigator’s Choice Chemotherapy in HER2 low, Hormone Receptor Positive Breast Cancer Patients whose disease has Progressed on Endocrine Therapy in the Metastatic Setting (DESTINY Breast 06).

Breast Cancer

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Genentech MO42319 Kate 3
Open

A Phase III, placebo controlled study of the efficacy and safety of Trastuzumab Emtansine in combination with Atezolizumab or placebo in patients with HER2-positive and PD-L1 positive locally advanced or metastatic breast cancer who have received prior Trastuzumab (+/- Perstuzumab) and Taxane based therapy.

Breast Cancer, Lung Cancer

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Blue Note PROT001
Closed

A double blinded, randomized, controlled, adaptive trial to compare effectiveness of two digital software medical devices (attune and cerena) as interventions for physical and emotional health in adjunctive oncology treatment, in order to determine relative impact on anxiety and depressive symptoms in stage I-III breast cancer and I-II non-small cell lung cancer.

Breast Cancer

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Sermonix SMX 18-001
Closed

An open-label, randomized, multicenter study evaluation the activity of Lasofoxifene relative to Fulvestrant for the treatment of pre- and postmenopausal women with locally advanced or metastatic ER+/HER2- breast cancer with an ESR1 mutation

Breast Cancer

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Odonate ODO-TE-B301
Closed

A Multinational, Multicenter, Randomized, Phase 3 Study of Tesetaxel plus a Reduced Dose of Capecitabine versus Capecitabine Alone in Patients with HER2 Negative, Hormone Receptor Positive, Locally Advanced or Metastatic Breast Cancer Previously Treated with a Taxane

Breast Cancer

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AstraZeneca D5336C00001
Closed

A Phase II, open label, randomised, multi-centre study to assess the safety and efficacy of agents targeting DNA damage repair in combination with Olaparib versus Olaparib monotherapy in the treatment of metastatic triple negative breast cancer patients stratified by alterations in homologous recombinant repair (HRR)-related genes (including BRCA1/2)

Pancreatic Cancer

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IPSEN Bioscience D-US-60010-001
Closed

Phase III, open-label, randomized, study to assess efficacy and safety of the irinotecan liposome injection (Liposomal Irinotecan) +oxaliplatin+5-FU/LV combination regimen vs nabpaclitaxel+gemcitabine in patients with MPC

Waldenstroms - TN or RR

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Beigene 001131-216
Open

Single-Arm, Expanded Access Study of Zanubrutinib (BGB-3111) in Patients with B-cell Malignancies This is a multicenter expanded access study of zanubrutinib monotherapy for patients with B-cell malignancies who are ineligible to enroll into any available zanubrutinib clinical studies

Multiple Myeloma

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GlaxoSmithKline GSK207495 DREAMM 3
Open

Phase III, open-label, study to evaluate the efficacy and safety of single agent Belantamab Mafodotin vs Pomalidomide plus low dose Dexamethasone (pom/dex) in participants with Relapsed/Refractory Multiple Myeloma (RRMM)

Multiple Myeloma

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Glaxo Smith Kline GSK MM 207495
Open

A Phase III, open Label, Randomized Study to Evaluate the Efficacy and Safety of Single-Agent Belantamab Mafodotin Compared to Pomalidomide plus Low-dose Dexamethasone (pom/dex) in participants with Relapsed Refractory Multiple Myeloma (DREAMM 3) who has undergone SCT or is considered transplant ineligible and received at least 2 Prior lines of therapy (including Lenalidomide and proteasome inhibitor).

Advanced Solid Tumors (ROS1, PIK3CA, ALK AKT1/2/3, HER2, PTEN, RET)

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Genentech MyTactic ML42439
Closed

An Open-label phase II study evaluating targeted therapies in patients who have advanced solid tumors with genomic alterations or protein expression patterns predictive of response

Advanced Solid Tumors (ROS1, PIK3CA, ALK AKT1/2/3, HER2, PTEN, RET)

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NAPO – NP303-102
Open

A Phase 3 multicenter, randomized, double-blind placebo-controlled trial evaluating crofelemer for the prophylaxis of diarrhea in adult patients with solid tumors receiving targeted-cancer therapies with or without standard chemotherapy regimens